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IGF-1 plays a central role in tissue repair and cell growth but should be used cautiously due to its proliferative effects. Pollak, Nature Reviews Cancer Stacking HGH and IGF-1 increases potential benefitsbut also compounds side effect risks if not carefully managed

This can result in a higher level of reactive oxygen and eventual necrosis in liver cells (Jaeschke et al., 2012)

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A special fibre jacket (artificial annulus) has been developed to mimic the AF in the so-called NP explant system, creating a physiological model to test the efficacy of regenerative therapies for IVD degeneration [15, 17]

Cesaro, A