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The intermediate metabolite -ketoglutarate (-KG) has important roles in regulating cancer cell metabolism and growth 15,16,17

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Given that oxidized proteins are prone to degradation (34), we hypothesized GSH depletion could result in a lower level of FASN protein in liver

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For instance, lactate-induced H3K18la promotes RUBCNL/Pacer transcription, facilitating autophagosome maturation through the Beclin1 interaction, which contributes to CRC cell survival and resistance to bevacizumab treatment

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