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Although these studies demonstrate widespread metal bioaccumulation, they collectively reveal a critical knowledge gap regarding the physiological and histopathological consequences of such contamination

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It contains chlorogenic acids and other compounds that still stimulate mild adrenal activity and cortisol release, though the effect is significantly smaller than regular coffee

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Figure 4 Concurrently, the ATP deficiency resulting from hypoxia promotes the disintegration of organelles and cell membranes, producing substantial amounts of oxygen free radicals and inflammatory mediators, which further intensify cellular damage and apoptosis (80)