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A study by Pickart and Margolina found that GHK-Cu peptides provoked significant skin regeneration benefits Skin Regenerative and Anti-Cancer Actions of Copper Peptides Pickart and Margolina Copper Peptides and Skin Hydration Studies have demonstrated that GHK-Cu peptides promote the development of glycosaminoglycans (such as hyaluronic acid)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 83.Spisni E., Valerii M., Manerba M., Strillacci A., Polazzi E., Mattia T., Griffoni C., Tomasi V

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Most researchers report sustained benefits lasting 4 to 6 months post-cycle, which is why cycles are typically repeated only two to three times annually