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The results indicated that the extracts with the highest activity against the LOX enzyme were those obtained through treatments performed at temperatures between 25 and 47.5 C, solid/solvent ratio between 1:75 and 1:125, and amplitudes between 40 and 60% (Figure 5d and Supplementary Table S3)

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elegans homolog of GCLC , gcs-1 , was cleaved by IRE1 and that cleavage was inhibited by 48c (Fig