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Elevated levels of ROS and iron in haematopoietic cells lacking the H-ferritin gene lead to a reduction in T-cell populations ( Figure 2 ) (112)

Koetting MC, Peters JT, Steichen SD, Peppas NA

(4) Furthermore, the oxidative stress imbalance, caused by excessive ROS production, impairs the antioxidant defense system by directly damaging antioxidant enzymes (such as SOD and GPx) and depleting key antioxidant molecules like glutathione, leading to fragmentation of hyaluronic acid in the extracellular matrix and abnormal collagen cross-linking, thereby reducing the mechanical properties of cartilage (6, 22, 23)

The wide-ranging binding properties were similar to those of albumin in blood plasma and the name ligandin was therefore coined (Litwack et al., 1971)

Based on the abundance of neutrophils in bone and their known contributions to cancer progression [8], we previously investigated the role of neutrophils in the prostate tumor-bone microenvironment

Biomaterials Research