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Under oxidative stress and induced by excessive ROS generation, Nrf2 is released from its inhibitor Keap1, allowing its translocation into the nucleus (Kasprzak et al., 2020), where it binds to the antioxidant response element (ARE) present in the DNA sequence of numerous antioxidant enzymes like glutathione-S-transferase, -glutamyl cysteine synthetase (glutamate cysteine ligase), heme oxygenase 1, and paraoxonase-1 inducing their transcription, managing the phase II response to oxidative stress (Kasprzak et al., 2020)

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Fast BDNF serum level increase and diurnal BDNF oscillations are associated with therapeutic response after partial sleep deprivation

Antioxidant foods: Citrus fruits, berries, and avocados support regeneration of glutathione

Furthermore, arginine helps fish detoxify ammonia through the urea cycle, which is particularly important during stress when protein breakdown is accelerated [91]

Special cases: In patients with neurological symptoms, the frequency may be initially more frequent and maintained at shorter intervals for a longer period of time