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More research is needed to understand vitamin Ds role in atrial fibrillation

Mechanistically, -Syn oligomers interact with mitochondrial respiratory chain complex I, impairing its function, leading to mitochondrial membrane potential depolarization, and promoting the release of proapoptotic factors into the cytoplasm

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Deleterious off-target effects in women 10 years or more past menopause, such as ovarian, endometrial, and breast cancers, intravascular thrombosis, cardiovascular episodes, and stroke, and suppression of endogenous testosterone and libido and increased risk of prostate cancer in men, have precluded broad clinical applications (Stevenson and Thornton, 2007)

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MCP-1 is increased in expression after mouse AVF creation and becomes a mediator of AVF dysfunction and failure