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Its intrinsic properties, including high cell permeability, the ability to easily cross both the bloodbrain and placenta barriers, and its role as an endogenous reservoir of free radical scavengers (with indirect extra activities), confer it beneficial uses as an adjuvant in the biomedical field

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If adding amylin agonism to a single GLP-1 agonist (CagriSema) produces 20.4% weight loss, the theoretical potential of adding it to a triple agonist is significant

PMID 33931001