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Importantly, along with an induction of HIF1, in SCD erythroblasts cultured in the absence of hemin, we detected a significantly decreased CBS expression under hypoxia compared to normoxia (Supplementary Fig

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(143), NO donors such as nitroglycerin can attenuate this PD-L1 upregulation, thereby restoring T-cell cytotoxicity

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doi: 10.1111/j.1600-0714.1990.tb00779.x