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On rare occasion, a patient may experience tiny bumps beneath the skin, a rash, headache, or itchy skin

This means that high serum B12 levels can persist for some time after large supplemental doses

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For gastrointestinal use, it is commonly discussed for gut irritation, gastritis-type symptoms, reflux-type irritation, inflammatory gut symptoms, and mucosal support

This differs from patient to patient, and it often depends on the severity of the symptoms and any underlying health issues