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In contrast, there was no significant increase in periosteal bone formation in similarly treated wild-type animals, suggesting that IGF-1 and mechanical load act synergistically to stimulate periosteal bone formation (Kesavan et al., 2011)

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These suggested that the increased expression of nuclear p53 and progerin in intrahepatic cells could be strongly linked to cell premature senescence in human liver fibrosis

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106 Schizophrenia has also been associated with oxidative stress and reduced GSH levels in the brain

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