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It differs from native IGF-1 by having an arginine substitution at the third amino acid (R3) and an additional 13 amino acids at the N-terminus, making it significantly more potent in receptor activation studies

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In the other trial (Deutsche Kardiale Autonome Neuropathie Studie), 73 patients with non-insulin-dependent diabetes mellitus and cardiac autonomic neuropathy were randomly assigned to the treated group (n = 39