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While human data is more limited, case reports from 2025-2026 suggest similar benefits in clinical practice, with women reporting improved mobility and reduced pain during menstruation

In this study, the ZIL exhibited lower toxicity than DMSO from viewpoints of cell viability and cell behaviours

Hydrochloric acid and/or sodium hydroxide may have been added during manufacture to adjust the pH (range 4.5-7.0)

However, isotope-labeled IS are often expensive or unavailable for certain compounds and using a single isotope-labeled IS for multiple structurally diverse compounds is inappropriate due to differences in retention times, matrix effects, ion suppression, fragmentation patterns, and ionization efficiencies

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Mees, S