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While iron-based Fenton reactions produce hydroxyl radicals (OH), their effectiveness requires an acidic environment, prompting exploration of metals like Mn and Cu that offer superior catalytic performance [76]

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The concentration of Mn-SOD increases as a protective response to inflammation and OS, and down-regulates NF-kappa B, activator protein-1, and MAPK pathways [250]

Intermittent or metronomic dosing could preserve antioxidant capacity in nonlesional compartments yet sustain cumulative oxidative stress in EESCs (89)