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Stretch marks develop when the skin is rapidly stretched, which can occur during: Pregnancy Puberty Weight gain or loss Rapid muscle growth The underlying cause of stretch marks involves the disruption of collagen and elastin fibers, essential components that provide skin with its strength and elasticity

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Conversely, lysosomes from LYSET KO cells contained dramatically increased amounts of both cleaved and uncleaved GNPT3HA, accompanied by several prominent degradation intermediates (Fig

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