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P2Y 2 receptor agonists, denufosol (OLIYNYK et al., 2010), were promising for their ability to activate alternative chloride secretion pathways, but both of these agonists have not been pursued further due to not meeting primary study goals of improving FEV 1 (Ratjen et al., 2012) and having a narrow effective concentration range, respectively (OLIYNYK et al., 2010)

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However, not everyone is a candidate for these medications, and others might prefer to explore alternatives

When evaluating peptides, consider the quality of evidence, personal health history, and your healthcare providers guidance