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Dosage doesn't work like that here consistency at a moderate dose beats an aggressive dose taken inconsistently, every time

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Kaya and colleagues have shown that disruption of the circadian cycle could influence nerve regenerationrats which had been kept at a normal 12 h light/dark cycle under treatment with melatonin during daytime have responded to the therapy better than rats which had been kept at inverted lightatnight cyclicity and treated at night (Kaya et al., 2013)

and Ralph, S.J., 2007