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Indeed, rare deactivating mutations in Akt or upstream proteins cause insulin resistance [9] and reduced activation of Akt or its upstream proteins has been observed in insulin-resistant muscle and adipose tissues of mice [10,11], rats [12] and humans [1319]

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Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences

Zhang, Y., Marcillat, O., Giulivi, C., Ernster, L

Iron typically damages cells in the heart, liver and elsewhere, which can cause significant adverse effects including coma, metabolic acidosis, shock, liver failure, coagulopathy, adult respiratory distress syndrome, long-term organ damage, and even death [63]