Proton pump inhibitor therapy and potential long-term harm
Travel support
Stevens LA, Claybon MA, Schmid CH, Chen J, Horio M, Imai E, et al
2019:chap 50
To move Epitalon from experimental to evidence-based, several developments are essential: Randomized, double-blind, placebo-controlled clinical trials, ideally targeting specific endpoints (sleep, immune aging, telomere attrition) Toxicology and long-term safety studies, including exploration of stereoisomer effects and off-target consequences Validated delivery systems (e.g., dendrimer-conjugates, transdermal patches) that make real-world use feasible Pharmacodynamic biomarkers, to identify responders and track efficacy objectively over time Epitalon is not snake oil, but its also not a magic bullet
Mechanistic studies explaining how peptides work, valuable for understanding but not proving clinical efficacy