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Pooyandjoo, M., et al

Potential benefits of Tirzepatide: Greater weight loss than Semaglutide in many studies Improved glycemic control Reduced appetite Improved metabolic markers Comparing These Five Therapies | Therapy | Primary Target | Main Goal | |---|---|---| | AOD-9604 | Fat metabolism | Fat mobilization | | MOTS-c | Mitochondria / AMPK | Metabolic optimization | | Tesamorelin | GHRH receptor | Reduce visceral fat | | Semaglutide | GLP-1 receptor | Appetite reduction | | Tirzepatide | GLP-1 + GIP receptors | Maximum weight loss | Which Therapy Produces the Most Weight Loss

doi:10.1056/NEJMoa2206038