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Acta Endocrinol (Copenh) 1991;124:583

Fe 2+ leaves the intestinal epithelial cells through the pathway mediated by FPN1 when the intracellular iron is too high ( 2+ is oxidized to Fe 3+ and tightly bound to transferrin (TF) at a ratio of 2:1

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Higher doses reached that plateau later in the trial. In a 112-week step-down trial, participants maintained 21.9% loss on the top dose, 16.6% after stepping down to 5 mg, and 9.9% on placebo