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Evolution, expression, and substrate specificities of aldehyde oxidase enzymes in eukaryotes

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The second step is a conformational rearrangement of Tyr9 leading to a direct interaction of Tyr9 with carbon C6

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Arch Neurol 67(6):731738 Matsuda N, Kitami T, Suzuki T, Mizuno Y, Hattori N, Tanaka K (2006) Diverse effects of pathogenic mutations of Parkin that catalyze multiple monoubiquitylation in vitro