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The therapeutic effects of Spirulina have been attributed to its rich content of bioactive metabolites, including phycocyanin, -carotene, and phenolic acids, which exhibit strong antioxidant, anti-inflammatory, and lipid-lowering properties (Khan et al., 2005)

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These distal peripheral afferents possess chemosensitivity which could prolong visceral sensitization and induce post-inflammatory effects ( Alteration in Gut-Brain Axis The brain-gut axis (GBA) is a bidirectional communication system between the gut and the brain

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