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For example, the anti-inflammatory medication valdecoxib was voluntarily withdrawn in 2005 due to safety concerns relating to cardiovascular events and life-threatening skin reactions after a decade on the market, while the psoriasis drug efalizumab was also voluntarily withdrawn in 2009 due to an association with progressive multifocal leukoencephalopathy, a rare and fatal central nervous system disease

Lancet 407 , 892908 (2026)

Iron deficiency anemia deserves separate consideration even if ferritin is technically "normal." Autoimmune conditions, including alopecia areata and lupus, can present with hair loss

For example, in G6PD-deficient individuals, residual hepatic enzyme activity can prove insufficient in stress states where increased G6PD activity is required, as in neonates with comorbid G6PD deficiency and Gilberts syndrome, who are at increased risk for hyperbilirubinemia (96, 97)