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Originally developed as an anti-obesity drug candidate in the late 1990s, it has since found research applications in both metabolic studies and cartilage repair investigations

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J Leukoc Biol 102(2):343349 Fridlender ZG et al (2009) Polarization of tumor-associated neutrophil phenotype by TGF-beta: N1 versus N2 TAN

Matrix metalloproteinase inhibition in a murine model of cavitary tuberculosis paradoxically worsens pathology

If the reaction is considered in isolation, a negative relationship between the GSH:GSSG ratio and DHAR activity would be predicted, because the enzyme consumes GSH and produces GSSG