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PMID 16687029

However, you will often have to pay co-pays or other fees at your doctors office, so it is important to talk to the injection provider before you arrange your first B12 shots

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Possible Side Effects Mild side effects of Vitamin B12 may include: ( 12 ) Mild pain, itching, or swelling at the injection site Temporary nausea or headache Mild diarrhea Hot flashes Vomiting These side effects do not affect all patients and are generally temporary and mild While rare, more serious side effects of Vitamin B12 injections can include ( 12 ): Irregular heartbeat Heart palpitations Hives or skin rash If you notice any severe reactions to a Vitamin B12 shot, contact a medical professional immediately

Unopened vials can be stored at room temperature for up to 2 years when kept sealed, dry, and protected from light