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In fact, HIEC proliferation and TEER significantly increases when co-cultured simultaneously with both cell types, advocating for the importance of developing complex OoC systems that can generate more biologically relevant outputs

Yet in practice, they produce completely different outcomes for completely different purposes, and choosing the wrong one means months of wasted effort targeting the wrong mechanism entirely

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Most customers report noticing a difference within two to four weeks of consistent daily use, with more pronounced results developing over 60 to 90 days

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