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In this situation, it can be challenging to demonstrate B12 deficiency even when there are typical symptoms (including neuropathy-like paraesthesia and numbness), as serum B12 concentrations may be just within, or sometimes above, the normal range due to the oral supplementation

However, this skin disorder is common in people with diabetes who inject insulin subcutaneously every day

Products in the 2% to 4% range often carry descriptions like "intensive," "advanced," or "professional strength." Four percent represents a common ceiling for face and neck applications in daily-use products

10.1016/j.physbeh.2014.10.033 187

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