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Specifically, animal studies show MPs can disrupt the -diversity of gut microbiota and decrease the Firmicutes-to-Bacteroidetes (F/B) ratio, resulting in an increased relative abundance of pathogenic bacteria in ICR mice (Wang et al., 2002), which are critical factors in the pathogenesis of neurodegenerative diseases

doi: 10.1016/j.bbrc.2016.11.062 83 ZhouJKhodakovDAEllisAVVoelckerNH

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222 In addition to the previous issues, NADs face manufacturing and scalability challenges