observed a high frequency of promoter hypermethylation and progressive loss of GPx3 expression in Barretts esophagus and its associated lesions, and these authors also confirmed the known function of GPx3 as a potent antioxidant [54]
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Neuronal effect High oxygen utilization, huge amounts of polyunsaturated fatty acids, elevated levels of free iron ions and low antioxidants defenses all together make the brain tissue vulnerable to reactive oxygen species injuries (48)
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