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Due to chemisorption, the sulfhydryl groups in glutathione can combine with silver nanoparticles to produce AgS bonds, which attach to the silver nanoparticles surface and generate a large number of hot spots, resulting in the enhancement of the infrared signal intensity of glutathione

Despite adherence challenges, clinical studies report encouraging signals

Based on these conflicted results, the association was speculated to be related to the clinical features of the population, stages of the disease, severity of copper excess, and types of detected specimens in these studies (Table 1)

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A lower GSH:GSSG ratio may indicate increased oxidative burden, environmental stress exposure, metabolic strain, or impaired recovery capacity