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doi:10.1097/md.0000000000020027 5

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doi: 10.3389/fimmu.2023.1139589 Received 07 January 2023 Accepted 20 March 2023 Published 18 April 2023 Volume 14 - 2023 Edited by Qun Zhao, Fourth Hospital of Hebei Medical University, China Reviewed by Laiping Zhong, Shanghai Jiao Tong University, China

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This hormonal effect accounts for sexual characteristics changes in immune function, and the higher susceptibility of women to autoimmune diseases like SLE ( It will be crucial to distinguish the interplay of gut microbiota and the sex hormones as it can potentially unlock the mechanisms of higher susceptibility of females to SLE and also unveil novel avenues of therapeutic intervention by manipulation of the gut microbiome for controlling disease course ( 3 Probiotics and systemic lupus erythematosus Probiotics are live microorganisms significant for their role in immunomodulation in SLE patients, as they restore gut microbiota balance and enhance immune function

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