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B12 bound to HC is not taken up by cells and thus, is biologically inactive ( via endocytosis using a specific CD320 receptor ( via CblF ( This free cytoplasmic B12 undergoes a series of intracellular transport and modifications to enable two core enzymatic reactions: 1) adenosyl-B12 acts as a co-factor for the enzyme methylmalonyl-coA mutase that catalyzes the conversion of methylmalonyl-coA to succinyl-coA, thereby enabling restoration of tricarboxylic acid (TCA) cycle intermediates and 2) methyl-B12 enables methionine synthase in the re-methylation of homocysteine to methionine using methyl-tetrahydrofolate (MTHF) as a methyl donor, thereby enabling the vital biochemical pathways of the folate cycle and methionine cycle, facilitating the downstream synthesis of important compounds like DNA and RNA (Figure 2)
Key Functions of Vitamin B12: Red blood cell formation Nervous system maintenance DNA synthesis Fatty acid metabolism Energy production Signs of B12 Deficiency Not getting enough Vitamin B12 can cause health problems
And on a side note we also have a much better understanding of why our metabolism slows down as we get older
My Experience With Digestive Issues and Lupus As we all know, our lupus symptoms can vary so much and will effect us all differently
When diagnosed and reported, these concurrent conditions support the accurate depiction of a patient's overall medical status
