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As noted earlier, damaged or released mtDNA activates innate immune pathways such as cGAS-STING and NLRP3, sustaining chronic inflammation and inflammaging (81, 90)

Measurement of serum creatinine and cystatin C are more convenient and rapid tests for evaluating kidney function

Asparagine is important in the removal of toxic ammonia from the body

Recovery & tissue repair Researched as a ghrelin-receptor agonist in preclinical work on GH-linked tissue-repair and recovery pathways

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Estrogen Metabolism Support Optimizing hepatic Phase I and Phase II estrogen detoxification reduces the burden of potentially carcinogenic estrogen metabolites (particularly 4-OH and 16-OH estrone) and may reduce estrogen-driven fibroid growth: DIM (diindolylmethane): Shifts estrogen metabolism toward the favourable 2-OH pathway Calcium-D-glucarate: Inhibits -glucuronidase, preventing deconjugation and reabsorption of estrogens in the gut (Note: off-the-shelf detox kits from health food stores are not equivalent to therapeutic doses of these specific compounds) N-acetylcysteine (NAC): Supports glutathione synthesis and Phase II sulphation 3