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Mechanism of Action IGF-1 LR3 has been investigated for its agonist activity at the type 1 IGF receptor (IGF-1R), a receptor tyrosine kinase

Higher concentrations may paradoxically reduce collagen birefringence, suggesting an inverse relationship between cell infiltration rate and matrix organization that warrants further mechanistic investigation

The combined activation of all three pathways is hypothesised to produce more pronounced and sustained weight reduction, though the long-term clinical implications of each receptor's contribution remain to be fully established

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J Pharm Bioallied Sci (2011) 3(3):4667