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One should consider the primary phase lesion and hemorrhaging that results from mechanical damage during SCI as well as the secondary phase lesion that lasts several hours or even several months and is accompanied by edema, hemorrhage, inflammation, and cytotoxic edema [44,45,46,47] and may extend to the white matter area and lead to white matter degeneration and damage [48, 49]

While knee OA has traditionally been considered a degenerative disease, advancements in regenerative medicine are breaking new ground, halting and even reversing cartilage erosion, and giving new hope to knee OA sufferers

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