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While fluoro-A85380 and raclopride showed a moderate cerebral uptake, befloxatone, buprenorphine as well as flumazenil exhibited a high cerebral uptake in human brain and also a high permeability across the in vitro system

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Studies have demonstrated that the lifespan of mice with OC is considerably reduced owing to the continuous activity of N1ICD, which leads to the aging of endothelial cells, increased expression of chemokines and the adhesion molecule VCAM1, and facilitates recruitment of neutrophils and invasion of tumors (70,74)

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L., Nelson, K., Huizenga, P., Hansen, R., Soundy, T

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