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GPx isoenzymes are all antioxidant enzymes that reduce potentially damaging reactive oxygen species (ROS), such as hydrogen peroxide and lipid hydroperoxides, to harmless products like water and alcohols by coupling their reduction with the oxidation of glutathione (Figure 2a )

To move the field forward, each mechanism needs to be considered through the use of model organisms and interventional trials, individually and in concert

By inducing vascular dysfunction, inflammation, and oxidative stress, it becomes a key driver of aging in multiple organs such as the heart, brain, and kidneys

B Lymphocyte commitment program is driven by the proto-oncogene c-Myc