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Ezrin, moesin, CD44, ICAM-1, and the tyrosine kinase receptor ErbB2 are recruited

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It remains to be seen how common is NPC1 upregulation is cancers that use macropinocytosis for cholesterol uptake, and when the first clinically approved macropinocytosis inhibitors will be developed

Strong oxidants such as hydrogen peroxide (H 2 O 2 ) instead readily modify protein thiols beyond reversible redox states, to form sulfinic (-SO 2 H) and sulfonic acids (-SO 3 H), thus preventing conversion into the disulfide-linked pathological species dsNNTTR