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Summary Glycocalyx degradation in SAP is not limited to a single organ but represents a systemic vascular endothelial insult, resulting from widespread inflammatory and enzymatic activation

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Ahn S, Kaipparettu BA

This depletion impairs the activation of G-protein-coupled receptors and histone deacetylation, which are essential for regulating brain inflammatory responses

& Parsonnet, M

The higher dose (300 mg/kg) produced significant restoration of hematological and biochemical parameters, reduction of inflammatory markers, and preservation of joint architecture comparable to the standard drug leflunomide