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Healthcare professionals have not identified any serious side effects from high-dose vitamin B12 supplementation
LB, AS, and EL performed the investigation
This neurodegeneration is accompanied by the formation of characteristic Lewy bodies, which are intracellular inclusions composed largely of aggregated and misfolded -synuclein ( This degeneration of dopaminergic neurons is strongly linked to the generation of reactive oxygen species and oxidative stress as well as mitochondrial dysfunction, neuroinflammation, and aging (Smeyne and Smeyne, 2013)
This efficacy limitation, rather than safety concerns, halted further development