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Nestler JE, Jakubowicz DJ, et al

Regional neurochemical profiles in the human brain measured by (1)H MRS at 7 T using local B(1) shimming

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These effects of Pycnogenol on joints can be explained by previous findings, showing that regular intake of Pycnogenol leads to a potent decrease of pro-inflammatory markers like NF-B and COX-enzymes, as well as a decline in the release of matrix metallopeptidase (MMP) enzymes, that are responsible for destroying cartilage in joints ( In most cases, joint pain is due to damage to the articular cartilage

For instance, DAAs express high levels of GFAP, a common marker of astrocyte activation (Liddelow et al., 2017)