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Copper-zinc imbalance and excitatory tone Low zinc removes an important brake on NMDAR activity and GABA balance

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International journal of dermatology, 55(2), 153157

The TrxR2 enzyme is encoded by the TXNRD2 gene located on chromosome 22q11.21 and is composed of 22 exons that generate six alternatively spliced mRNAs resulting in six different isoforms of TrxR2

Ascorbate and glutathione can individually participate in ROS detoxification operations, but their essential role results from their association in the context of the ascorbate-glutathione cycle (AGC), also called the Halliwell-Asada-Foyer cycle, after the scientists who identified it (see Focus on Hydroperoxide detoxification)

Elevated iron levels can also support microbial growth, hindering the body's inflammatory responses and leading to an increased risk of infections