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Francescone RB, Vendramini-Costa D, Franco-Barraza J, Wagner J, Muir A,Lau AN,Gabitova L, Pazina T,Gupta S, Luong TRDMalik R,Thapa RJ,Restifo D,Zhou Y,Cai KQ,Hensley HH,Tan Y,Kruger WD,Devarajan K, Balachandran S, Klein-Szanto AJ, Wang H, El-Deiry WS

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However, these medications have several important limitations: (1) delayed onset of therapeutic action, typically requiring weeks to months for clinical effect

rxlist.com (Enlon ) Keywords Organophosphate Cholinesterase Inhibitors Echothiophate Trade Name: Phospholine Iodide Drug Class: Anticholinesterase ( Organophosphate ) Mechanism of Action: for topical use to enhance the effect of endogenously liberated acetylcholine in the iris, ciliary muscle, and other parasympathetically innervated structures of the eye Irreversible long-acting cholinesterase inhibitor It causes miosis, increases the outflow of aqueous humor, causes a fall in intraocular pressure, and potentiation of accommodation Indications: Historically used for treatment of glaucoma but currently very rarely used, and frequently regarded as obsolete for the routine treatment of glaucoma (Figure 1)

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