& Appetecchia, M
proposed that Ang II expression is associated with mood disorders and that reducing brain Ang II levels might decrease anxiety and depression in animal models (57)
Nerve growth factor (NGF), released by osteoblasts, endothelial cells, and infiltrating immune cells, plays a key role in promoting this ectopic innervation, establishing a direct link between structural bone changes and pain signaling ( via its receptor DCC, has been shown to drive the sprouting of calcitonin gene-related peptide (CGRP)+ nociceptive fibers in the subchondral bone, thereby contributing directly to pain hypersensitivity associated with OA (Zhu et al., 2019)
The perimenopause fat redistribution pattern, specifically the shift toward abdominal and flank storage, is partly a GH-decline phenomenon, not only an estrogen-decline phenomenon
If you are uncomfortable with injections, discuss this with your provider
Can I use this cream under makeup