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However, if these protective measures fail, the lesion can grow and accumulate genetic and epigenetic abnormalities, ultimately leading to the development of a malignant tumor [196]

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Each simulation was fully equilibrated in both the atmosphere and deep ocean following a three-stage spin-up protocol so that each simulation is fully equilibrated: (1) the globally and volume-integrated annual mean ocean temperature trend is less than 1 C per 1,000 years, (2) trends in surface air temperature are less than 0.3 C per 1,000 years, and (3) net energy balance at the top of the atmosphere, averaged over a 100 year period at the end of the simulation, is less than 0.25 W m 2