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From a molecular viewpoint, key mechanistic themes have emerged: microbial metabolites such as SCFAs, tryptophan metabolites, and bile acids can penetrate into the CNS or signal via the vagus, modulating microglial activation, astrocytic support, and even neuronal gene expression
According to the function of mitophagy and the pathogenesis of DPN, it can be speculated that mitophagy may play an important role in DPN
Among these pathways, Alzheimer disease, Serotonergic synapse, Calcium signaling pathway, Amyotrophic lateral sclerosis (ALS), Glutamatergic synapse, Cholesterol metabolism, Long-term potentiation, Phagosome, Immune system, and TNF signaling pathway belong to at least two perspectives (Fig
mansoni (107 KB PDF) Figure S2
Abrogation of ARF6 promotes RSL3-induced ferroptosis and mitigates gemcitabine resistance in pancreatic cancer cells