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Sies H, Belousov VV, Chandel NS, Davies MJ, Jones DP, Mann GE, et al

IGF-1 elevation cascade Sustained GH drives sustained hepatic IGF-1 production - the downstream effector behind most clinical GH-axis outcomes

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Native amylin is co-secreted with insulin after meals and signals satiety, slows gastric emptying, and blunts post-meal glucagon

BPC-157 targets growth factor pathways (EGF, TGF-) while GHK-Cu hits collagen synthesis and broader epigenetic remodeling