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Thus, this leads to very short half-lives compared to traditional small-molecule drugs [3]

10.1186/s12958-018-0343-0 157 XueZ.ChenX.LiJ

A peptide that survives the stomach still faces intestinal brush border peptidases, limited transepithelial transport, and hepatic first-pass metabolism

Additionally, the pAcF has become a widely applied ncAA in bioconjugate chemistry, particularly for antibody conjugation applications, owing to its well-established genetic encoding systems and proven biocompatibility profiles 24,25,26

Similar results have been observed in studies involving the MCL and other connective tissues

However, your provider has done a lot of research on this and other reported risks and can fully explain this to you